Y H M Krul-Poel, C Snackey, Y Louwers, P Lips, C B Lambalk, J S E Laven, S Simsek
The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review
Eur J Endocrinol 169 (6) 853-865, 2013
Context Metabolic disturbances, in particular, insulin resistance (IR) and dyslipidemia, are common in women suffering from polycystic ovary syndrome (PCOS). Evidence is accumulating that vitamin D status may contribute to the development of metabolic disturbances in PCOS.
Objective The aim of this study was to carry out a systematic review addressing the association between vitamin D status, vitamin D receptor polymorphisms, and/or polymorphisms related to vitamin D metabolism and metabolic disturbances in women with PCOS.
Design and methods A systematic search of electronic databases was carried out up to January 2013 for observational studies and clinical trials in women suffering from PCOS with outcome measures that were related to vitamin D status. We conducted univariate and multivariate regression analyses of the weighted means to gain insights into the association between vitamin D, BMI, and IR based on existing literature.
Results We found 29 eligible trials with inconsistency in their results. One well-designed randomized controlled trial has been carried out until now. Univariate regression analyses of the weighted means revealed vitamin D to be a significant and independent predictor of IR in both PCOS and control women. The significance disappeared after adjustment for BMI in PCOS women.
Conclusions Current evidence suggests an inverse association between vitamin D status and metabolic disturbances in PCOS. Owing to the heterogeneity of the studies, it is hard to draw a definite conclusion. The causal relationship between vitamin D status and metabolic disturbances in PCOS remains to be determined in well-designed placebo-controlled randomized clinical trials.
Nikos Vlahos, Athanasios Vlachos, Olga Triantafyllidou, Nikolaos Vitoratos, George Creatsas
Continuous versus cyclic use of oral contraceptives after surgery for symptomatic endometriosis: a prospective cohort study
Fertil Steril 2013;100:1337–42
Micah J. Hill, Brian W. Whitcomb, Terrence D. Lewis, Mae Wu, Nancy Terry, Alan H. DeCherney, Eric D. Levens, Anthony M. Propst
Progesterone luteal support after ovulation induction and intrauterine insemination: a systematic review and meta-analysis
Fertil Steril 2013;100:1373–80
Ana Julissa Serrano, Leire Begona, Eduardo Anitua, Raquel Cobos, Gorka Orive
Systematic review and meta-analysis of the efficacy and safety of alendronate and zoledronate for the treatment of postmenopausal osteoporosis
Gynecol Endocrinol, 2013; 29(12): 1005–1014
Costantino Di Carlo, Virginia Gargano, Stefania Sparice, Giovanni A. Tommaselli, Giuseppe Bifulco, Carmine Nappi
Effects of an oral contraceptive containing estradiol valerate and dienogest on circulating androgen levels and acne in young patients with PCOS: an observational preliminary study
Gynecol Endocrinol, 2013; 29(12): 1048–1050
Sanaz Ghazal, Lubna Pal
Perspective on hormone therapy 10 years after the WHI
Maturitas 76 (2013) 208–212
Gabriela J. Prutsky, Juan Pablo Domecq, Vishnu Sundaresh, Tarig Elraiyah, Mohammed Nabhan, Larry J. Prokop, Adrian Vella, Victor M. Montori, Mohammad Hassan Murad
Screening for Gestational Diabetes: A Systematic Review and Meta-Analysis
J Clin Endocrinol Metab 98: 4311– 4318, 2013
Andrea Dunaif, Bart C. J. M. Fauser
Renaming PCOS—A Two-State Solution
J Clin Endocrinol Metab 98: 4325– 4328, 2013